Senior Scientist - Genetics

Scheduled Hours 40 Position Summary The Senior Scientist in the Cremins Lab will work with a dynamic team to conduct research in the area of sequencing and analysis of complex multimodal genomics data. Collaborate with the team to design, optimize, and standardize experimental and analysis pipelines to accelerate high-quality publications. Develop new code and statistical methods to analyze genomics and spatial transcriptomics datasets to map the neural connectome. They will also be responsible for maintaining and organizing lab records, training junior scientists on technical assays, preparing and reviewing manuscripts, and helping with grant applications.

Successful candidates will possess strong data processing skills in the UNIX/Linux environment and have familiarity with high-performance computing clusters. They will have experience in learning diverse data types generated by various platforms and technologies, including genomics, proteomics, imaging, and spatial transcriptomics data.

This role is ideal for you if you enjoy the excitement of a bleeding-edge scientific laboratory and welcome the challenge of serving as a steady consistent organizational and genomics scientist role in a fast-paced environment. Those who will thrive in the role are dedicated to collaboration and keen on playing an active role in maintaining excellent protocols, a clean, organized, and safe laboratory, and eager to lead themselves and others toward maintaining a warm, positive, and inclusive lab climate. Organized individuals with a can-do attitude, a passion for building unity and community within a larger laboratory, a knack for independent problem-solving and getting things done, and the ability to independently and positively create molecular and cellular data with attention to detail would excel in this role. Job Description

Primary Duties & Responsibilities:

• Collaborates on designing, conducting and reporting of research projects.
• Supervises and conducts Illumina linkering, library preparation for all genomics experiments, quantification, library pooling, and placing sequencing runs for the lab.
• Generates novel genomics and connectome datasets to understand structure-function relationships of neuronal genomes.
• Assists with grant preparation and reporting.
• Processes and analyzes imaging and sequencing data (image registration, segmentation, feature detection, clustering, anchoring to single cell datasets).
• Prepares and reviews papers on research.
• Develops new algorithms for analysis of RNA FISH, DNA FISH, and neural connectome in situ sequencing technologies.
• Collaborates fluidly with other computational experts to conduct efficient analyses leading to discovery in mammalian neuron genome structure-function data. In parallel, trains to understand the inner workings of loop, TAD, subTAD, and trans interaction code for genome folding in single-cell 3D genome data sets.
• Complies with established safety procedures and maintains required documentation on laboratory and specimen conditions.
• Performs other duties as assigned.

Working Conditions:

• Works in a laboratory environment with potential exposure to biological, chemical and radioactive hazards.
• Must be physically able to wear protective equipment and to provide standard care to research animals.

The above statements are intended to describe the general nature and level of work performed by people assigned to this classification. They are not intended to be construed as an exhaustive list of all job duties performed by the personnel so classified. Management reserves the right to revise or amend duties at any time. Required Qualifications

Education:

Phd Or Terminal Degree Or Combination Of Education And Experience May Substitute For Minimum Education.

Certifications:

No specific certification is required for this position.

Work Experience:

Postdoctoral (3 Years)

Skills:

Not Applicable

Driver's License:

A driver's license is not required for this position. More About This Job

Preferred Qualifications:

• PhD in cell biology or neuroscience and 5+ years of postdoctoral experience is highly preferred.
• Experience in cell culture, 3D genome architecture, multi-omics, spatial transcriptomics, mouse genetics, and behavioral and circuit neuroscience.
• Experience with Illumina library preparation and handling NextSeq1000/2000 and Novaseq instruments is highly preferred.
• Experience in histology and fluorescence microscopy is highly preferred.
• Experience in Python/R programming language, Linux environment, and cluster computing.
• Experience in statistical analysis.

Preferred Qualifications

Education:

No additional education beyond what is stated in the Required Qualifications section.

Certifications:

No additional certification beyond what is stated in the Required Qualifications section.

Work Experience:

No additional work experience beyond what is stated in the Required Qualifications section.

Skills:

Analytical Problem Solving, Cell Cultures, Cluster Computing, Fluorescence Microscopy, Genomics, Histology, Laboratory Instrumentation, Laboratory Processes, Laboratory Techniques, Linux, Mouse Genetics, Neuroscience Research, Omics, Oral Communications, Python (Programming Language), R Programming, Statistical Analysis, Teamwork, Working Independently, Written Communication Grade R12 Salary Range $63,400.00 - $115,000.00 / AnnuallyThe salary range reflects base salaries paid for positions in a given job grade across the University. Individual rates within the range will be determined by factors including one's qualifications and performance, equity with others in the department, market rates for positions within the same grade and department budget. Questions

For frequently asked questions about the application process, please refer to our External Applicant FAQ .

Accommodation

If you are unable to use our online application system and would like an accommodation, please email CandidateQuestions@wustl.edu or call the dedicated accommodation inquiry number at ... and leave a voicemail with the nature of your request.

All qualified individuals must be able to perform the essential functions of the position satisfactorily and, if requested, reasonable accommodations will be made to enable employees with disabilities to perform the essential functions of their job, absent undue hardship. Pre-Employment Screening All external candidates receiving an offer for employment will be required to submit to pre-employment screening for this position. The screenings will include criminal background check and, as applicable for the position, other background checks, drug screen, an employment and education or licensure/certification verification, physical examination, certain vaccinations and/or governmental registry checks. All offers are contingent upon successful completion of required screening. Benefits Statement

Personal

• Up to 22 days of vacation, 10 recognized holidays, and sick time.

• Competitive health insurance packages with priority appointments and lower copays/coinsurance.

• Take advantage of our free Metro transit U-Pass for eligible employees.

• WashU provides eligible employees with a defined contribution (403(b)) Retirement Savings Plan, which combines employee contributions and university contributions starting at 7%.

Wellness

• Wellness challenges, annual health screenings, mental health resources, mindfulness programs and courses, employee assistance program (EAP), financial resources, access to dietitians, and more!

Family

• We offer 4 weeks of caregiver leave to bond with your new child. Family care resources are also available for your continued childcare needs. Need adult care? Weve got you covered.

• WashU covers the cost of tuition for you and your family, including dependent undergraduate-level college tuition up to 100% at WashU and 40% elsewhere after seven years with us.

For policies, detailed benefits, and eligibility, please visit:

EEO Statement Washington University in St. Louis is committed to the principles and practices of equal employment opportunity and especially encourages applications by those from underrepresented groups. It is the Universitys policy to provide equal opportunity and access to persons in all job titles without regard to race, ethnicity, color, national origin, age, religion, sex, sexual orientation, gender identity or expression, disability, protected veteran status, or genetic information.Washington University is dedicated to building a community of individuals who are committed to contributing to an inclusive environment fostering respect for all and welcoming individuals from diverse backgrounds, experiences and perspectives. Individuals with a commitment to these values are encouraged to apply.