Senior Scientist I, Protein Analytics, Biologics Discovery Sciences

AbbVie's mission is to discover and deliver innovative medicines and solutions that solve serious health issues today and address the medical challenges of tomorrow. We strive to have a remarkable impact on people's lives across several key therapeutic areas - immunology, oncology, neuroscience, and eye care - and products and services in our Allergan Aesthetics portfolio. For more information about AbbVie, please visit us at www.abbvie.com. Follow @abbvie on X, Facebook, Instagram, YouTube, LinkedIn and Tik Tok.

Job Description

We are seeking a highly motivated Senior Scientist I with a diverse protein biochemistry background to join our Protein Analytics team within our Biotherapeutic Discovery Production group. The team is responsible for characterizing purity and key product quality attributes of candidate molecules to advance those with the greatest probability of success as well as guiding protein engineering and production path development activities.

The successful candidate will be focused on implementing and conducting various assays to monitor process impurities and to assess the function of Biotherapeutics with the aim of fully characterizing lead/candidate molecules and identifying potential molecular liabilities. Some of the techniques/methods utilized in the position include 1) released glycan assay (RGA) using BioAccord LC-MS system; 2) surface plasmon resonance (SPR) using Biacore for assessment of antigen binding and binding of antibody Fc receptors; and 3) isoelectric focusing (IEF) and capillary electrophoresis (CE). The role also includes assessment of thermal/chemical stability to extend understanding of potential liabilities and inform engineering efforts and candidate selection. The position will be responsible for developing and implementing new technologies/platforms that improve the efficiency of the overall drug-discovery process for multispecific therapeutic proteins as well as data tracking and reporting and will require collaboration with the production group and other analytics teams.

Key Responsibilities:

• Implement and conduct assays to monitor process impurities and to assess the function of Biotherapeutics such as RGA, SPR, IEF, CE-SDS, etc.
• Identify, develop, and implement new technologies/platforms that improve the efficiency of the overall drug-discovery process for multispecific therapeutic proteins.
• Maintain a high level of productivity in the lab, conducting research independently and managing several projects simultaneously. Independently design, execute, and interpret experimental results. Caretaking and troubleshooting key instrumentation.
• Optimize workflows to address evolving timelines and priorities by integrating automation into platform methods.
• Contribute to project teams and work effectively across functional groups to help advance programs.
• Stay current with applicable internal/external scientific literature and