Principal Research Scientist I, Protein Biochemistry

AbbVie's mission is to discover and deliver innovative medicines and solutions that solve serious health issues today and address the medical challenges of tomorrow. We strive to have a remarkable impact on people's lives across several key therapeutic areas - immunology, oncology, neuroscience, and eye care - and products and services in our Allergan Aesthetics portfolio. For more information about AbbVie, please visit us at www.abbvie.com. Follow @abbvie on X, Facebook, Instagram, YouTube, LinkedIn and Tik Tok.

Job Description

AbbVie is looking for talented Protein Biochemists with strong Protein Sciences expertise to join our team at our headquarters in the Chicago area. This exciting role is central to advancing small molecule drug discovery across a variety of disease areas using innovative biochemical strategies. As an integral member of our team, you will drive projects and collaborate across functions to develop robust and scalable protein workflows and address strategic questions in support of key drug discovery activities, including assay development, screening, structure-based design, and exploratory biology.

Success in this position requires a solid foundation and proven track record in Protein biochemistry and related fields, good understanding and applications of computational protein design tools, and strong collaborative skills.

Key Responsibilities:

• Innovate and lead experimental plans to address essential questions about protein functions and overcome challenges in generating protein /protein complexes with low yield, aggregation issues.
• Enhance and implement best practices in protein expression, purification, and characterization to support drug discovery programs.
• Design complex protein constructs and guide purification processes to enable cutting-edge biochemical/biophysical assays and structural biology research.
• Serve as the technical expert in protein production, utilizing advanced chromatographic techniques on AKTA systems.
• Effectively use of advanced computational tools and the development of novel approaches to strengthen our program capabilities.
• Work closely with project teams to identify and solve key questions within the domain of protein biochemistry.
• Stay ahead of scientific discoveries to integrate valuable insights into evolving protein engineering strategies.
• Lead cross-functional teams, driving biochemistry-focused initiatives that enhance program success.

Qualifications

• Bachelor's Degree or equivalent education and typically, 14 years of experience, Master's Degree or equivalent education and typically 12 years of experience, PhD and typically 6 years of experience.
• Demonstrated expertise in producing high-quality proteins and tackling complex challenges.
• Proficiency in programming and the application of bioinformatics tools and computational biology technologies is a plus.
• Comprehensive understanding of the best practices in the field of membrane protein is advantageous.
• Solid experience with nanobody generation technologies.
• Exceptional organizational and time-management skills, with an independent and detail-oriented approach to problem-solving.
• Strong project management skills, capable of leading and contributing to multiple simultaneous projects.
• Excellent collaborative and communication skills, adaptable to both computational and non-computational scientific audiences.

Additional Information

Applicable only to applicants