Staff Scientist, Assay Development and Integration
- Nautilus Biotechnology Inc.
- San Carlos, California
- Full Time
Staff Scientist, Assay Development and Integration
Location
San Carlos
Employment Type
Full time
Location Type
On-site
Department
Reagent & Platform Development
Compensation
$164K - $221K Offers Equity
The hiring pay range for this position is based on skills, education and experience relevant to the role; title may be assessed one level lower or higher, accordingly. Other components of total compensation include a competitive options grant at the time of hire (with potential for additional grants).
Benefits include medical, vision, and dental insurance, group and supplemental life insurance, 401k retirement plan, responsible (unlimited) paid time off, parental leave, and more.
Overview
Application
At Nautilus, we have a big and important mission: improve the health of millions by unleashing the potential of the proteome to accelerate drug development and enable a new world of precision and personalized medicine. We are developing a single-molecule protein analysis platform of unprecedented sensitivity, scale, and ease of use that we believe will democratize access to the proteome - one of the most dynamic and valuable sources of biological insight. To accomplish this, we are pursuing deep, hard science with an entrepreneurial mindset and creating a world-class team of builders, innovators, and dreamers across a wide range of disciplines.
Do you love tinkering at the interface of assay development and instrument integration? Is protocol improvement an unshakable habit? We are looking for an outstanding Staff Scientist who is passionate about building and commercializing the assays that drive the proteome platform at Nautilus.
Platform Assay Integration plays a central role at Nautilus. The team resides at the intersection of science, engineering, and operations to deliver game-changing proteomics technologies. We are looking for a flexible and collaborative self-starter with extensive experience designing, executing, analyzing & interpreting complex, multi-factorial experiments. The ability to understand and utilize complicated instrumentation is required. Strong troubleshooting skills, critical thinking, and attention to detail are essential. The right candidate will enthusiastically leverage their experience, curiosity and creativity to collaborate & innovate in areas of assay development, platform integration, protocol optimization, and product development.
Responsibilities
Design and develop robust assays and reagents with simple elegant workflows.
Execute complex, information-rich experiments that provide decisive development direction.
Solve platform integration problems related to single-molecule detection including fluidics, optics, surface chemistry, bioreagents, and software.
Work collaboratively with cross-functional teams to identify failure modes and improve assay performance.
Drive root cause and permanent corrective actions to resolve issues as they arise.
Conduct detailed data analyses, use bioinformatic pipelines, and provide data-driven recommendations.
Use Python or similar programming languages to analyze and synthesize large datasets
Transfer new methodologies and assays from R D to Reagent Development and Operations.
Provide clear and concise written and oral communications to colleagues and supervisors.
Establish a culture of teamwork, accountability, quality, timeliness of execution with a service-oriented, internal/external customer focus.
Provide technical mentorship to junior team members.
Qualifications
A minimum of a PhD in Molecular biology, Biochemistry, Bioengineering, Chemical engineering, Biophysics, Chemistry, Material Science, or related field with 10+ years industry experience; or BS/MS with 15+ years' experience in related biotechnology or material science field.
Experience with single-molecule experiments and analysis techniques
Demonstrated record of innovation developing molecular biology assays and techniques.
Experience developing robust workflows using proteins, nucleic acids, nanoparticles, and small molecules.
Experience working with complex instrumentation with integrated optics, fluidics, and assay workflows.
Proven ability to work collaboratively on cross-functional teams in a highly dynamic environment.
Exceptional data analysis skills, with strong analytical abilities and attention to detail.
Proficiency in Python or similar language for analysis of large datasets
Ability to learn quickly and willingness to work determinedly at a dynamic start-up company.
Nautilus Team Culture
We are curious go-getters: this is a team of life-long learners who aren't afraid to tackle the big challenges and we embrace the journey.
We are detail oriented: we do great science by working smart & with diligence. We learn from our mistakes.
We are easy to work with: we want our workplace to be one where everyone can share their perspective and be treated with respect and kindness.
Location
San Carlos
Employment Type
Full time
Location Type
On-site
Department
Reagent & Platform Development
Compensation
$164K - $221K Offers Equity
The hiring pay range for this position is based on skills, education and experience relevant to the role; title may be assessed one level lower or higher, accordingly. Other components of total compensation include a competitive options grant at the time of hire (with potential for additional grants).
Benefits include medical, vision, and dental insurance, group and supplemental life insurance, 401k retirement plan, responsible (unlimited) paid time off, parental leave, and more.
Overview
Application
At Nautilus, we have a big and important mission: improve the health of millions by unleashing the potential of the proteome to accelerate drug development and enable a new world of precision and personalized medicine. We are developing a single-molecule protein analysis platform of unprecedented sensitivity, scale, and ease of use that we believe will democratize access to the proteome - one of the most dynamic and valuable sources of biological insight. To accomplish this, we are pursuing deep, hard science with an entrepreneurial mindset and creating a world-class team of builders, innovators, and dreamers across a wide range of disciplines.
Do you love tinkering at the interface of assay development and instrument integration? Is protocol improvement an unshakable habit? We are looking for an outstanding Staff Scientist who is passionate about building and commercializing the assays that drive the proteome platform at Nautilus.
Platform Assay Integration plays a central role at Nautilus. The team resides at the intersection of science, engineering, and operations to deliver game-changing proteomics technologies. We are looking for a flexible and collaborative self-starter with extensive experience designing, executing, analyzing & interpreting complex, multi-factorial experiments. The ability to understand and utilize complicated instrumentation is required. Strong troubleshooting skills, critical thinking, and attention to detail are essential. The right candidate will enthusiastically leverage their experience, curiosity and creativity to collaborate & innovate in areas of assay development, platform integration, protocol optimization, and product development.
Responsibilities
Design and develop robust assays and reagents with simple elegant workflows.
Execute complex, information-rich experiments that provide decisive development direction.
Solve platform integration problems related to single-molecule detection including fluidics, optics, surface chemistry, bioreagents, and software.
Work collaboratively with cross-functional teams to identify failure modes and improve assay performance.
Drive root cause and permanent corrective actions to resolve issues as they arise.
Conduct detailed data analyses, use bioinformatic pipelines, and provide data-driven recommendations.
Use Python or similar programming languages to analyze and synthesize large datasets
Transfer new methodologies and assays from R D to Reagent Development and Operations.
Provide clear and concise written and oral communications to colleagues and supervisors.
Establish a culture of teamwork, accountability, quality, timeliness of execution with a service-oriented, internal/external customer focus.
Provide technical mentorship to junior team members.
Qualifications
A minimum of a PhD in Molecular biology, Biochemistry, Bioengineering, Chemical engineering, Biophysics, Chemistry, Material Science, or related field with 10+ years industry experience; or BS/MS with 15+ years' experience in related biotechnology or material science field.
Experience with single-molecule experiments and analysis techniques
Demonstrated record of innovation developing molecular biology assays and techniques.
Experience developing robust workflows using proteins, nucleic acids, nanoparticles, and small molecules.
Experience working with complex instrumentation with integrated optics, fluidics, and assay workflows.
Proven ability to work collaboratively on cross-functional teams in a highly dynamic environment.
Exceptional data analysis skills, with strong analytical abilities and attention to detail.
Proficiency in Python or similar language for analysis of large datasets
Ability to learn quickly and willingness to work determinedly at a dynamic start-up company.
Nautilus Team Culture
We are curious go-getters: this is a team of life-long learners who aren't afraid to tackle the big challenges and we embrace the journey.
We are detail oriented: we do great science by working smart & with diligence. We learn from our mistakes.
We are easy to work with: we want our workplace to be one where everyone can share their perspective and be treated with respect and kindness.
Job ID: 486361517
Originally Posted on: 7/22/2025
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