Sr. Research Associate -Molecular Immuno

Sr. Research Associate -Molecular Immunology
Primary Duties

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The Yoh resource is expected to apply expertise across several practical skills in support of the Client's Vaccines R&D Global Immunology function, including spectral flow cytometry, peripheral blood mononuclear cell (PBMC) processing, B cell staining and sorting, high-throughput immunoglobulin repertoire sequencing (both 10x Genomics and plate-based approaches), bioinformatics analysis of antibody sequences, and downstream functional assessment using various platforms.

The role is a lab-based research associate who will be participating in various teams to support preclinical and early clinical evaluation of vaccine candidates against various respiratory viruses. Knowledge of immunoassay-based instruments, including flow cytometers, cell sorters, multi-mode plate readers and plate washers will be required. Individual will be performing laboratory work including immunoassays, recording data in specified formats and/or recording detailed day-to-day work in electronic laboratory notebook; reagent preparation; lab housekeeping and maintenance. There will be requirement to work with animal and human blood, serum, plasma and other samples sources. Applicant must be capable of working both independently and as part of a structured team.

Responsibilities include but are not limited to:

Participate in design, planning, optimization and execution of studies to set up end-to-end B cell analytics pipeline integrating wet-lab and computational workflows.
Participate in optimization and implementation of assays (serological and cell-based) for analysis of immune responses to vaccine candidates.
Upon appropriate training perform technical procedures and operate a variety of lab instrumentation platforms related to Immunology.
Perform PBMC isolation, B cell staining, and sorting (FACS) for repertoire analyses.
Conduct immunoglobulin sequencing using both 10x Genomics and plate-based methods.
Support library preparation, quality control, and sample tracking throughout the sequencing pipeline.
Support bioinformatics analyses to process and interpret antibody repertoire datasets.
Execute and analyze binding and epitope characterization assays using Carterra or comparable platforms.
Upon training analyze and summarize experimental outcomes, record experimental procedures and raw and analyzed data in electronic laboratory notebook.
Participate as required in team meetings, project discussions, and data review sessions.
Comply with the company safety policies and minimize risk to self, others, and the environment, consistent with the community and industry standards.
Education and Experience Requirements:

BS +2-4 years or MS +1-2 years of relevant experience in industry or academia.
Degree should be in Immunology, Virology, Molecular Biology or related field.
Hands-on experience with RNA/DNA (deoxyribonucleic acid/ ribonucleic acid) extraction,... For full info follow application link.

Yoh, a Day & Zimmermann company, is an Equal Opportunity Employer, M/F/D/V.