Research Scientist I

AskBio Inc., a wholly owned and independently operated subsidiary of Bayer AG, is a fully integrated gene therapy company dedicated to developing life-saving medicines and changing lives. The company maintains a portfolio of clinical programs across a range of neuromuscular, central nervous system, cardiovascular, and metabolic disease indications with a clinical-stage pipeline that includes investigational therapeutics for congestive heart failure, limb-girdle muscular dystrophy, multiple system atrophy, Parkinson's disease, and Pompe disease. AskBio's gene therapy platform includes Pro10, an industry-leading proprietary cell line manufacturing process, and an extensive array of capsids and promoters. With global headquarters in Research Triangle Park, North Carolina, and European headquarters in Edinburgh, Scotland, the company has generated hundreds of proprietary capsids and promoters, several of which have entered pre-clinical and clinical testing.

Our vision: Pioneering science to create transformative molecular medicines.

Our mission: Lead innovative science and drive clinical outcomes to transform people's lives.

Our principles:

• Advance innovative science by pushing boundaries.

• Bring transformative therapeutics to patients in need.

• Provide an environment for employees to reach their fullest potential.

Our values:

• Be a Pioneer. We are not afraid of the impossible and to innovate to make gene therapies accessible to those in need.

• Cultivate Collaboration. Strive to be the best teammate, actively listen, openly communicate, and embrace diverse points of view.

• Embrace Responsibility. We are humbled by the enormity of our mission. We hold a relentless commitment to advance science and clinical outcomes for our patients, families, and caregivers.

• Raise the Bar. Continuously drive improvements and efficiencies. Seek and provide constructive feedback. Have a bias for learning and action.

• Act with Uncompromising Integrity. Be honest, transparent, and committed to doing what's right in every situation. Make clear commitments and follow through.

Summary Overview

The Research Scientist I, reporting to the Director of Upstream Process Development, will support the Process Development team by identifying, evaluating, and implementing new and existing technologies to improve process efficiency, control, and understanding. This role involves developing scalable AAV vector manufacturing processes using AskBio's proprietary Pro10 cell line. This role also involves designing and executing experiments for preclinical and clinical programs, applying Quality by Design (QbD) principles to generate high-quality datasets.

This position will be based at AskBio's headquarters facility in Research Triangle Park (Durham), North Carolina.

Job Responsibilities

• Develop scalable AAV vector manufacturing methods using AskBio's proprietary Pro10 cell line
• Independently design and execute flask and bioreactor experiments in support of preclinical and clinical programs using QbD principles
• Generate and interpret data independently, to efficiently deliver high quality data sets supporting platform and preclinical pipelines.
• In collaboration with senior leads contribute to CMC strategy and project plans.
• Provide technical expertise and critical thinking to effectively operate in cross functional teams supporting delivery of R&D pipeline
• Supervising junior staff, advising on lab work as appropriate.
• Contribute to tech transfer documents and summary reports.
• Author CMC regulatory documents as required.
• Review and communicate experimental results both orally and in written reports/presentations to colleagues and management.
• Collaborate with vendors and evaluate media and feed formulations to optimize AAV productivity.
• Identify CapEx needs.
• Identify, evaluate, and implement new and existing technologies to improve process efficiency, control, and understanding

Minimum Requirements

• Biology/Biochemistry/Chemistry/Chemical Engineering or equivalent with an MS degree and 6+ years of experience or PhD with 0-2 years of experience
• Previous experience with bench-top and/or mini-bioreactor formats required
• Demonstrable knowledge of bioreactor theory and scale-up approaches
• Statistical software experience (JMP, Minitab, etc.) preferred
• Previous viral vector and/or AAV experience a plus
• Understanding of QbD principles and application preferred

Asklepios BioPharmaceutical, Inc. (AskBio) is an Equal Opportunity Employer and does not discriminate against any employee or applicant for employment because of race, color, religion, gender, sexual orientation, gender identity, national origin, age, disability, veteran status or any other protected status prohibited under Federal, State or local laws. All employment decisions are based on valid jobrelated requirements. If you are a qualified individual with a disability or a disabled veteran and are unable or limited in your ability to use or access our website, you may request a reasonable accommodation to express interest in a specific opening by calling us at ... or emailing us at ....

Asklepios BioPharmaceutical, Inc. (AskBio) is an Equal Opportunity Employer and does not discriminate against any employee or applicant for employment because of race, color, religion, gender, sexual orientation, gender identity, national origin, age, disability, veteran status or any other protected status prohibited under Federal, State or local laws. All employment decisions are based on valid jobrelated requirements. If you are a qualified individual with a disability or a disabled veteran and are unable or limited in your ability to use or access our website, you may request a reasonable accommodation to express interest in a specific opening by calling us at ... or sending us an email at ....

Agencies: Please do not contact any employee at AskBio about this requisition. Any resume submitted by a recruitment agency to any employee at AskBio, through any medium, will be deemed the sole property of AskBio unless the agency was engaged by AskBio Talent Acquisition team to recruit for that position. All agencies must have a prior executed service agreement with AskBio prior to any search engagement. If a candidate who was submitted outside of the AskBio agency process is hired by AskBio, no fee or payment of any kind will be paid to the agency.